The 4th Central German Meeting on Bioinformatics, known as the Mittelerde Meeting 2019, will be held on June 13 and 14 at the Biotechnology Center TU Dresden (BIOTEC). The BIOTEC is part of the Center for Molecular and Cellular Bioengineering (CMCB) and develops innovative technologies driving the progress of modern life sciences. It is the perfect place to host and strengthen the computational biology community of central Germany. We sincerely invite bioinformatics researchers and all those interested to be part of the meeting and to submit a contribution. On Friday evening, the event will be complemented by the Dresden Long Night of Science that allows you to vividly explore the excellent research conducted at the CMCB. Beyond science, the conference is followed up by the famous cultural festival Bunte Republik Neustadt. Mittelerde 2019 is the perfect occasion for an extended stay in Dresden.